OpenVaccine Updates: How Eterna players designed superfolder mRNAs and how Stanford researchers tested them - Hannah Wayment-Steele, PhD The first authorized COVID-19 vaccines were based on messenger RNA molecules that promote translation of SARS-CoV-2 antigen proteins. However, these vaccines have been logistically problematic for delivery to developing countries and to rural populations in developed countries. We will talk about how Eterna players designed "superfolder" mRNAs that were predicted to be more resistant to degradation, how researchers at the Das and Barna groups at Stanford validated their increased stability and translation, and what the next frontiers are for designing improved RNA vaccines.